A meta-analysis of neuropsychological markers of vulnerability to suicidal behavior in mood disorders.

TitleA meta-analysis of neuropsychological markers of vulnerability to suicidal behavior in mood disorders.
Publication TypeJournal Article
Year of Publication2014
AuthorsRichard-Devantoy S, Berlim M, Jollant F
JournalPsychol Med
Volume44
Issue8
Pagination1663-73
Date Published2014 Jun
ISSN1469-8978
KeywordsAdult, Biomarkers, Decision Making, Disease Susceptibility, Executive Function, Female, Humans, Male, Middle Aged, Mood Disorders, Neuropsychological Tests, Suicide, Attempted
Abstract

BACKGROUND: Suicidal behavior results from a complex interplay between stressful events and vulnerability factors, including cognitive deficits. However, it is not clear which cognitive tests may best reveal this vulnerability. The objective was to identify neuropsychological tests of vulnerability to suicidal acts in patients with mood disorders.METHOD: A search was made of Medline, EMBASE and PsycINFO databases, and article references. A total of 25 studies (2323 participants) met the selection criteria. A total of seven neuropsychological tests [Iowa gambling task (IGT), Stroop test, trail making test part B, Wisconsin card sorting test, category and semantic verbal fluencies, and continuous performance test] were used in at least three studies to be analysed.RESULTS: IGT and category verbal fluency performances were lower in suicide attempters than in patient controls [respectively, g = -0.47, 95% confidence interval (CI) -0.65 to -0.29 and g = -0.32, 95% CI -0.60 to -0.04] and healthy controls, with no difference between the last two groups. Stroop performance was lower in suicide attempters than in patient controls (g = 0.37, 95% CI 0.10-0.63) and healthy controls, with patient controls scoring lower than healthy controls. The four other tests were altered in both patient groups versus healthy controls but did not differ between patient groups.CONCLUSIONS: Deficits in decision-making, category verbal fluency and the Stroop interference test were associated with histories of suicidal behavior in patients with mood disorders. Altered value-based and cognitive control processes may be important factors of suicidal vulnerability. These tests may also have the potential of guiding therapeutic interventions and becoming part of future systematic assessment of suicide risk.

DOI10.1017/S0033291713002304
Alternate JournalPsychol Med
PubMed ID24016405
Grant List / / Canadian Institutes of Health Research / Canada

McGill Logo

CIUSSS ouest montreal logo

 



  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre