Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort.

TitleMediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort.
Publication TypeJournal Article
Year of Publication2017
AuthorsLuciano M, Corley J, Cox SR, Hernández MCValdés, Craig LCA, Dickie DAlexander, Karama S, McNeill GM, Bastin ME, Wardlaw JM, Deary IJ
JournalNeurology
Volume88
Issue5
Pagination449-455
Date Published2017 Jan 31
ISSN1526-632X
Abstract

OBJECTIVE: To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73-76 years).METHODS: We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline imaging data collection.RESULTS: In regression models adjusting for relevant demographic and physical health indicators, we found that lower adherence to the MeDi was associated with greater 3-year reduction in total brain volume (explaining 0.5% of variance, p < 0.05). This effect was half the size of the largest covariate effect (i.e., age). Cross-sectional associations between MeDi and baseline MRI measures in 562 participants were not significant. Targeted analyses of meat and fish consumption did not replicate previous associations with total brain volume or total gray matter volume.CONCLUSIONS: Lower adherence to the MeDi in an older Scottish cohort is predictive of total brain atrophy over a 3-year interval. Fish and meat consumption does not drive this change, suggesting that other components of the MeDi or, possibly, all of its components in combination are responsible for the association.

DOI10.1212/WNL.0000000000003559
Alternate JournalNeurology
PubMed ID28053008
PubMed Central IDPMC5278943
Grant ListG0701120 / / Medical Research Council / United Kingdom
G1001245 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
MR/M013111/1 / / Medical Research Council / United Kingdom