Maternal childhood adversity and child temperament: an association moderated by child 5-HTTLPR genotype.

TitleMaternal childhood adversity and child temperament: an association moderated by child 5-HTTLPR genotype.
Publication TypeJournal Article
Year of Publication2015
AuthorsBouvette-Turcot A-A, Fleming AS, Wazana A, Sokolowski MB, Gaudreau H, Gonzalez A, Deslauriers J, Kennedy JL, Steiner M, Meaney MJ
Corporate AuthorsMAVAN Research Team
JournalGenes Brain Behav
Date Published2015 Mar
KeywordsAdult, Child Abuse, Child, Preschool, Cohort Studies, Depression, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Longitudinal Studies, Mother-Child Relations, Polymorphism, Single Nucleotide, Pregnancy, Serotonin Plasma Membrane Transport Proteins, Temperament

We examined transgenerational effects of maternal childhood adversity on child temperament and a functional promoter polymorphism, 5-HTTLPR, in the serotonin-transporter gene (SLC6A4) as potential moderators of such maternal influences in 154 mother-child dyads, recruited into a longitudinal birth cohort study. We examined the interactive effects of maternal childhood experience using an integrated measure derived from Childhood Trauma Questionnaire (CTQ) and Parental Bonding Index (PBI). Triallelic genotyping of 5-HTTLPR was performed. A measure of 'negative emotionality/behavioural dysregulation' was derived from the Early Childhood Behaviour Questionnaire at 18 and 36 months. Negative emotionality/behavioural dysregulation was highly stable between 18 and 36 months and predicted psychosocial problems at 60 months. After controlling multiple demographics as well as both previous and concurrent maternal depression there was a significant interaction effect of maternal childhood adversity and offspring 5-HTTLPR genotype on child negative emotionality/behavioural dysregulation (β = 1.03, t(11,115) = 2.71, P < .01). The results suggest a transgenerational effect of maternal developmental history on emotional function in the offspring, describing a pathway that likely contributes to the familial transmission of vulnerability for psychopathology.

Alternate JournalGenes Brain Behav.
PubMed ID25688466
Grant List / / Canadian Institutes of Health Research / Canada