Maternal care differentially affects neuronal excitability and synaptic plasticity in the dorsal and ventral hippocampus.

TitleMaternal care differentially affects neuronal excitability and synaptic plasticity in the dorsal and ventral hippocampus.
Publication TypeJournal Article
Year of Publication2015
AuthorsNguyen H-B, Bagot RC, Diorio J, Wong TPan, Meaney MJ
JournalNeuropsychopharmacology
Volume40
Issue7
Pagination1590-9
Date Published2015 Jun
ISSN1740-634X
Abstract

Variations in early life maternal care modulate hippocampal development to program distinct emotional-cognitive phenotypes that persist into adulthood. Adult rat offspring that received low compared with high levels of maternal licking and grooming (low LG offspring) in early postnatal life show reduced long term potentiation (LTP) and impaired hippocampal-dependent memory, suggesting a 'detrimental' maternal effect on neural development. However, these studies focused uniquely on the dorsal hippocampus. Emerging evidence suggests a distinct role of the ventral hippocampus in mediating aggression, anxiety, and fear-memory formation, which are enhanced in low LG offspring. We report that variations in maternal care in the rat associate with opposing effects on hippocampal function in the dorsal and ventral hippocampus. Reduced pup licking associated with suppressed LTP formation in the dorsal hippocampus, but enhanced ventral hippocampal LTP. Ventral hippocampal neurons in low LG offspring fired action potentials at lower threshold voltages that were of larger amplitude and faster rise rate in comparison with those in high LG offspring. Furthermore, recordings of excitatory postsynaptic potential-to-spike coupling (E-S coupling) revealed an increase in excitability of ventral hippocampal CA1 neurons in low LG offspring. These effects do not associate with changes in miniature excitatory postsynaptic currents or paired-pulse facilitation, suggesting a specific effect of maternal care on intrinsic excitability. These findings suggest region-specific influences of maternal care in shaping neural development and synaptic plasticity.

DOI10.1038/npp.2015.19
Alternate JournalNeuropsychopharmacology
PubMed ID25598429
Grant List8632 / / Canadian Institutes of Health Research / Canada