Maternal Adverse Childhood Experience and Depression in Relation with Brain Network Development and Behaviors in Children: A Longitudinal Study.

TitleMaternal Adverse Childhood Experience and Depression in Relation with Brain Network Development and Behaviors in Children: A Longitudinal Study.
Publication TypeJournal Article
Year of Publication2021
AuthorsZhang H, Wong T-Y, Broekman BFP, Chong Y-S, Shek LP, Gluckman PD, Tan KHian, Meaney MJ, Fortier MV, Qiu A
JournalCereb Cortex
Volume31
Issue9
Pagination4233-4244
Date Published2021 07 29
ISSN1460-2199
Abstract

Maternal childhood maltreatment and depression increase risks for the psychopathology of the offspring. This study employed a longitudinal dataset of mother-child dyads to investigate the developmental trajectories of brain functional networks and behaviors of children in relation with maternal childhood adverse experience and depression. Maternal childhood trauma was retrospectively assessed via childhood trauma questionnaire, whereas maternal depressive symptoms were prospectively evaluated during pregnancy and after delivery (n = 518). Child brain scans were acquired at age of 4.5, 6, and 7.5 years (n = 163) and behavioral problems were measured at 7.5 years using the Child Behavior Checklist. We found the functional connectivity of the language network with the sensorimotor, frontal, and attentional networks as a function of maternal adverse experience that interacted with sex and age. Girls exposed to mothers with depressive symptoms or childhood abuse showed the increased development of the functional connectivity of the language network with the visual networks, which was associated with social problems. Girls exposed to mothers with depressive symptoms showed the slower growth of the functional connectivity of the language network with the sensorimotor networks. Our findings, in a community sample, suggest the language network organization as neuroendophenotypes for maternal childhood trauma and depression.

DOI10.1093/cercor/bhab081
Alternate JournalCereb Cortex
PubMed ID33825872
Grant List / / Singapore National Research Foundation /
/ / Translational and Clinical Research /
/ / Flagship Programme and administered /
/ / Singapore Ministry of Health's National Medical Research Council /