Lifetime History of Depression Predicts Increased Amyloid-β Accumulation in Patients with Mild Cognitive Impairment.

TitleLifetime History of Depression Predicts Increased Amyloid-β Accumulation in Patients with Mild Cognitive Impairment.
Publication TypeJournal Article
Year of Publication2015
AuthorsChung JKu, Plitman E, Nakajima S, Chow TW, Chakravarty MM, Caravaggio F, Gerretsen P, Brown EE, Iwata Y, Mulsant BH, Graff-Guerrero A
Corporate AuthorsAlzheimer's Disease Neuroimaging Initiative
JournalJ Alzheimers Dis
Date Published2015
KeywordsAged, Amyloid beta-Peptides, Analysis of Variance, Apolipoprotein E4, Brain Mapping, Cerebral Cortex, Databases, Factual, Depression, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Mild Cognitive Impairment, Positron-Emission Tomography

Mounting evidence associates a lifetime history of major depression (LMD) with an increased risk for Alzheimer's disease (AD). Studies have shown that major depression (MD) is strongly linked to pathophysiological markers of AD, such as cortical amyloid-β (Aβ) burden. However, no imaging studies have shown in vivo whether an LMD is linked to increased Aβ accumulation in patients with mild cognitive impairment (MCI) in four cortical regions that have been highly associated with increased Aβ deposition in previous literature: frontal, cingulate, parietal, and temporal. Drawing from the ADNI database, we found that patients with amnestic MCI (aMCI) and an LMD (n = 39) had significantly higher 18F-Florbetapir standardized uptake value ratios, a surrogate measure of Aβ deposition, mainly in the bilateral frontal cortex, compared to patients with aMCI without an LMD (n = 39) (p = 0.02). This difference was not explained by current depressive symptoms, vascular risk factors, or the use of different PET scanners. The results were reliable employing two independent methods for analysis: region-of-interest and voxel-based analyses. Increased Aβ in the bilateral frontal lobes may be a biomarker of depressive symptomology in aMCI patients. Further studies should test whether higher Aβ predicts future conversion into AD in this population.

Alternate JournalJ. Alzheimers Dis.
PubMed ID25633681
Grant ListU01 AG024904 / AG / NIA NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada