Lateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: A longitudinal study.

TitleLateral geniculate nucleus volume changes after optic neuritis in neuromyelitis optica: A longitudinal study.
Publication TypeJournal Article
Year of Publication2021
AuthorsPapadopoulou A, Oertel FC, Chien C, Kuchling J, Zimmermann HG, Siebert N, Motamedi S, Souza MD', Asseyer S, Bellmann-Strobl J, Ruprecht K, Chakravarty MM, Scheel M, Magon S, Wuerfel J, Paul F, Brandt AU
JournalNeuroimage Clin
Volume30
Pagination102608
Date Published2021
ISSN2213-1582
KeywordsAdult, Female, Geniculate Bodies, Humans, Longitudinal Studies, Middle Aged, Nerve Fibers, Neuromyelitis Optica, Optic Neuritis, Young Adult
Abstract

OBJECTIVES: Lateral geniculate nucleus (LGN) volume is reduced after optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD). We aimed at a longitudinal assessment of LGN volume in NMOSD.METHODS: Twenty-nine patients with aquaporin 4-IgG seropositive NMOSD (age: 47.8 ± 14.6 years (y), female: n = 27, history of ON (NMO-ON): n = 17, median time since ON: 3[1.2-12.1]y) and 18 healthy controls (HC; age: 39.3 ± 15.8y; female: n = 13) were included. Median follow-up was 4.1[1.1-4.7]y for patients and 1.7[0.9-3.2]y for HC. LGN volume was measured using a multi-atlas-based approach of automated segmentation on 3 Tesla magnetic resonance images. Retinal optical coherence tomography and probabilistic tractography of the optic radiations (OR) were also performed.RESULTS: At baseline, NMO-ON patients had lower LGN volumes (395.4 ± 48.9 mm) than patients without ON (NMO-NON: 450.7 ± 55.6 mm; p = 0.049) and HC (444.5 ± 61.5 mm, p = 0.025). LGN volume was associated with retinal neuroaxonal loss and microstructural OR damage. Longitudinally, there was no change in LGN volumes in the absence of ON, neither in all patients (B = -0.6, SE = 1.4, p = 0.670), nor in NMO-ON (B = -0.8, SE = 1.6, p = 0.617) and NMO-NON (B = 1.7, SE = 3.5, p = 0.650). However, in four patients with new ON during follow-up, LGN volume was reduced at last visit (median time since ON: 2.6 [1.8-3.9]y) compared to the measurement before ON (352 ± 52.7 vs. 371.1 ± 55.9 mm; t = -3.6, p = 0.036).CONCLUSION: Although LGN volume is reduced after ON in NMOSD, this volume loss is not progressive over longer follow-up or independent of ON. Thus, our findings -at least in this relatively small cohort- do not support occult neurodegeneration of the afferent visual pathway in NMOSD.

DOI10.1016/j.nicl.2021.102608
Alternate JournalNeuroimage Clin
PubMed ID33735786
PubMed Central IDPMC7974320