Interneuron activity leads to initiation of low-voltage fast-onset seizures.

TitleInterneuron activity leads to initiation of low-voltage fast-onset seizures.
Publication TypeJournal Article
Year of Publication2015
AuthorsShiri Z, Manseau F, Lévesque M, Williams S, Avoli M
JournalAnn Neurol
Volume77
Issue3
Pagination541-6
Date Published2015 Mar
ISSN1531-8249
Abstract

Seizures in temporal lobe epilepsy can be classified as hypersynchronous and low-voltage fast according to their onset patterns. Experimental evidence suggests that low-voltage fast-onset seizures mainly result from the synchronous activity of γ-aminobutyric acid-releasing cells. In this study, we tested this hypothesis using the optogenetic control of parvalbumin-positive interneurons in the entorhinal cortex, in the in vitro 4-aminopyridine model. We found that both spontaneous and optogenetically induced seizures had similar low-voltage fast-onset patterns. In addition, both types of seizures presented with higher ripple than fast ripple rates. Our data demonstrate the involvement of interneuronal networks in the initiation of low-voltage fast-onset seizures.

DOI10.1002/ana.24342
Alternate JournalAnn. Neurol.
PubMed ID25546300
PubMed Central IDPMC4880461
Grant List74609 / / Canadian Institutes of Health Research / Canada
8109 / / Canadian Institutes of Health Research / Canada
MOP119340 / / Canadian Institutes of Health Research / Canada

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