The influence of anxiety and depressive symptoms during pregnancy on birth size.

TitleThe influence of anxiety and depressive symptoms during pregnancy on birth size.
Publication TypeJournal Article
Year of Publication2014
AuthorsBroekman BFP, Chan Y-H, Chong Y-S, Kwek K, Cohen SSharon, Haley CLouise, Chen H, Chee C, Rifkin-Graboi A, Gluckman PD, Meaney MJ, Saw S-M
Corporate AuthorsGUSTO Research Group
JournalPaediatr Perinat Epidemiol
Volume28
Issue2
Pagination116-26
Date Published2014 Mar
ISSN1365-3016
KeywordsAdult, Anxiety, Asian Continental Ancestry Group, Birth Weight, Depression, Female, Fetal Development, Gestational Age, Humans, Infant, Newborn, Mothers, Pregnancy, Pregnancy Complications, Psychiatric Status Rating Scales, Risk Factors, Singapore, Surveys and Questionnaires
Abstract

BACKGROUND: Mental health problems during pregnancy can influence fetal growth. However, studies examining the influence of maternal mental health across the normal range of birth outcomes are uncommon. This study examined the associations between symptoms of maternal depression and anxiety during pregnancy on birth size among term Asian infants.METHODS: One thousand forty-eight Asian pregnant women from a cohort Growing Up in Singapore Towards Healthy Outcomes were recruited between 2009 to 2010 at two Singaporean maternity hospitals. At 26 weeks gestation, depressive symptoms were measured with the Edinburgh Postnatal Depression Scale (EPDS) and the Beck Depression Inventory II (BDI-II), and anxiety was measured with the Spielberger State-Trait Anxiety Inventory (STAI). Health personnel recorded birthweight, birthlength, gestational age, and head circumference at birth.RESULTS: Nine hundred forty-six women who delivered term infants had complete data. For this sample, the mean birthweight was 3146.6 g [standard deviation (SD) 399.0], the mean birthlength was 48.9 cm (SD 2.0). After controlling for several potential confounders, there was a significant negative association between STAI and birthlength [β = -0.248, confidence interval (CI) [-0.382, -0.115], P < 0.001] and a small negative association between EPDS and birthlength (β = -0.169, CI [-0.305, -0.033], P = 0.02). No associations were found between scores on the EPDS, BDI-II, and STAI with birthweight or head circumference.CONCLUSIONS: Our preliminary data suggest that among term infants, anxiety and depressive symptoms are not associated with birthweight, while anxiety and depressive symptoms are associated with a shorter birthlength.

DOI10.1111/ppe.12096
Alternate JournalPaediatr Perinat Epidemiol
PubMed ID24266599

  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre