Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.
Title | Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Erlangsen A, Appadurai V, Wang Y, Turecki G, Mors O, Werge T, Mortensen PB, Starnawska A, Børglum AD, Schork A, Nudel R, Bækvad-Hansen M, Bybjerg-Grauholm J, Hougaard DM, Thompson WK, Nordentoft M, Agerbo E |
Journal | Mol Psychiatry |
Date Published | 2018 Aug 16 |
ISSN | 1476-5578 |
Abstract | Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular studies are needed to identify loci accounting for genetic heritability. We conducted a genome-wide association study and estimated single nucleotide polymorphisms (SNP) heritability for a suicide attempt. In a case-cohort study, national data on all individuals born in Denmark after 1981 and diagnosed with severe mental disorders prior to 2013 (n = 57,377) and individuals from the general population (n = 30,000) were obtained. After quality control, the sample consisted of 6024 cases with an incidence of suicide attempt and 44,240 controls with no record of a suicide attempt. Suggestive associations between SNPs, rs6880062 (p-value: 5.4 × 10) and rs6880461 (p-value: 9.5 × 10), and suicide attempt were identified when adjusting for socio-demographics. Adjusting for mental disorders, three significant associations, all on chromosome 20, were identified: rs4809706 (p-value: 2.8 × 10), rs4810824 (p-value: 3.5 × 10), and rs6019297 (p-value: 4.7 × 10). Sub-group analysis of cases with affective disorders revealed SNPs associated with suicide attempts when compared to the general population for gene PDE4B. All SNPs explained 4.6% [CI-95: 2.9-6.3%] of the variation in suicide attempt. Controlling for mental disorders reduced the heritability to 1.9% [CI-95: 0.3-3.5%]. Affective and autism spectrum disorders exhibited a SNP heritability of 5.6% [CI-95: 1.9-9.3%] and 9.6% [CI-95: 1.1-18.1%], respectively. Using the largest sample to date, we identified significant SNP associations with suicide attempts and support for a genetic transmission of suicide attempt, which might not solely be explained by mental disorders. |
DOI | 10.1038/s41380-018-0218-y |
Alternate Journal | Mol. Psychiatry |
PubMed ID | 30116032 |
Grant List | R102-A9118 / / Lundbeckfonden (Lundbeck Foundation) / R102-A9118 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / R102-A9118 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / R102-A9118 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / R102-A9118 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / R102-A9118 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / R102-A9118 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / R102-A9118 / / Lundbeckfonden (Lundbeck Foundation) / R155-2014-1724 / / Lundbeckfonden (Lundbeck Foundation) / |