FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.
|Title||FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Cook D, Nuro E, Jones EV, Altimimi HF, W Farmer T, Gandin V, Hanna E, Zong R, Barbon A, Nelson DL, Topisirovic I, Rochford J, Stellwagen D, Béïque J-C, Murai KK|
|Date Published||2014 Nov 20|
|Keywords||5' Untranslated Regions, Animals, Behavior, Animal, Long-Term Potentiation, Memory, Long-Term, Mice, Knockout, Protein Biosynthesis, Receptors, AMPA, RNA, Messenger, RNA-Binding Proteins, Synapses|
Translational control of mRNAs allows for rapid and selective changes in synaptic protein expression that are required for long-lasting plasticity and memory formation in the brain. Fragile X Related Protein 1 (FXR1P) is an RNA-binding protein that controls mRNA translation in nonneuronal cells and colocalizes with translational machinery in neurons. However, its neuronal mRNA targets and role in the brain are unknown. Here, we demonstrate that removal of FXR1P from the forebrain of postnatal mice selectively enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP), and de novo GluA2 synthesis. Furthermore, FXR1P binds specifically to the 5' UTR of GluA2 mRNA to repress translation and limit the amount of GluA2 that is incorporated at potentiated synapses. This study uncovers a mechanism for regulating long-lasting synaptic plasticity and spatial memory formation and reveals an unexpected divergent role of FXR1P among Fragile X proteins in brain plasticity.
|Alternate Journal||Cell Rep|
|PubMed Central ID||PMC4254574|
|Grant List||1R21DA026053-01 / DA / NIDA NIH HHS / United States |
MOP111152 / / Canadian Institutes of Health Research / Canada
MOP123390 / / Canadian Institutes of Health Research / Canada
R21 DA026053 / DA / NIDA NIH HHS / United States