Estimating volumes of the pituitary gland from T1-weighted magnetic-resonance images: effects of age, puberty, testosterone, and estradiol.

TitleEstimating volumes of the pituitary gland from T1-weighted magnetic-resonance images: effects of age, puberty, testosterone, and estradiol.
Publication TypeJournal Article
Year of Publication2014
AuthorsWong APui-Yee, Pipitone J, Park MTae M, Dickie EW, Leonard G, Perron M, Pike BG, Richer L, Veillette S, M Chakravarty M, Pausova Z, Paus T
JournalNeuroimage
Volume94
Pagination216-21
Date Published2014 Jul 1
ISSN1095-9572
KeywordsAdolescent, Age Factors, Algorithms, Child, Estradiol, Female, Humans, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Organ Size, Pituitary Gland, Puberty, Reproducibility of Results, Sensitivity and Specificity, Sex Factors, Testosterone, Young Adult
Abstract

The pituitary gland is a key structure in the hypothalamic-pituitary-gonadal (HPG) axis--it plays an important role in sexual maturation during puberty. Despite its small size, its volume can be quantified using magnetic resonance imaging (MRI). Here, we study a cohort of 962 typically developing adolescents from the Saguenay Youth Study and estimate pituitary volumes using a newly developed multi-atlas segmentation method known as the MAGeT Brain algorithm. We found that age and puberty stage (controlled for age) each predicts adjusted pituitary volumes (controlled for total brain volume) in both males and females. Controlling for the effects of age and puberty stage, total testosterone and estradiol levels also predict adjusted pituitary volumes in males and pre-menarche females, respectively. These findings demonstrate that the pituitary gland grows during adolescence, and its volume relates to circulating plasma-levels of sex steroids in both males and females.

DOI10.1016/j.neuroimage.2014.02.030
Alternate JournalNeuroimage
PubMed ID24632090
Grant ListMOP178790 / / Canadian Institutes of Health Research / Canada

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