Emotion regulation in bipolar disorder type I: an fMRI study.

TitleEmotion regulation in bipolar disorder type I: an fMRI study.
Publication TypeJournal Article
Year of Publication2015
AuthorsCorbalán F, Beaulieu S, Armony JL
JournalPsychol Med
Volume45
Issue12
Pagination2521-31
Date Published2015 Sep
ISSN1469-8978
Abstract

BACKGROUND: Bipolar disorder type I (BD-I) is associated with emotion dysregulation. However, experimentally controlled studies of emotion regulation (ER), particularly those examining the brain correlates of the putative deficits, are scarce and their results inconsistent.METHOD: Nineteen euthymic BD-I patients and 17 healthy controls (HC) underwent functional magnetic resonance imaging while performing a visual ER 2 × 2 factorial task, with instruction (Look or Decrease) and valence (Negative or Neutral) as within-subject factors. Emotional ratings were collected after each picture presentation to assess regulation success.RESULTS: BD-I patients were successful at downregulating their emotions, although to a lesser degree than HC. Both groups engaged brain regions previously implicated in ER; however, unlike HC, patients engaged some of those regions, particularly the ventrolateral prefrontal cortex (VLPFC) in the Negative Look and Neutral Decrease conditions. Moreover, patients failed to show the reduced amygdala activation in the Negative Decrease condition observed in HC.CONCLUSION: Our findings suggest that BD-I patients are able to downregulate their emotions when instructed to do so. However, they also appear to engage their ER network, particularly the VLPFC, even when not required to do so. These findings may help explain their often-reported difficulty in regulating emotions in everyday life despite their attempts to do so.

DOI10.1017/S0033291715000434
Alternate JournalPsychol Med
PubMed ID25997918

  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre