The emerging role of exosomes in mental disorders.

TitleThe emerging role of exosomes in mental disorders.
Publication TypeJournal Article
Year of Publication2019
AuthorsSaeedi S, Israel S, Nagy C, Turecki G
JournalTransl Psychiatry
Volume9
Issue1
Pagination122
Date Published2019 03 28
ISSN2158-3188
Abstract

Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are enriched with small RNA, and they play a role in many physiological processes. In the brain, they are involved in processes including synaptic plasticity, neuronal stress response, cell-to-cell communication and neurogenesis. While exosomes have been implicated previously in cancer and neurodegenerative diseases, research regarding their role in mental disorders remains scarce. Given their functional significance in the brain, investigation in this field is warranted. Additionally, because exosomes can cross the blood-brain barrier, they may serve as accessible biomarkers of neural dysfunction. Studying exosomes may provide information towards diagnosis and therapeutic intervention, and specifically those derived from the brain may provide a mechanistic view of the disease phenotype. This review will discuss the roles of exosomes in the brain, and relate novel findings to current insights into mental disorders.

DOI10.1038/s41398-019-0459-9
Alternate JournalTransl Psychiatry
PubMed ID30923321
PubMed Central IDPMC6438960
Grant ListFDN148374 / / Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) / International
EGM141899 / / Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) / International

  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre