Electroencephalographic abnormalities and 5-year outcome in first-episode psychosis.

TitleElectroencephalographic abnormalities and 5-year outcome in first-episode psychosis.
Publication TypeJournal Article
Year of Publication2014
AuthorsManchanda R, Norman R, Malla A, Harricharan R, Northcott S, Richard J
JournalCan J Psychiatry
Date Published2014 May
KeywordsAdaptation, Psychological, Adolescent, Adult, Child, Comorbidity, Educational Status, Electroencephalography, Female, Follow-Up Studies, Humans, Male, Ontario, Patient Outcome Assessment, Predictive Value of Tests, Psychiatric Status Rating Scales, Psychotic Disorders, Social Adjustment, Substance-Related Disorders

OBJECTIVE: To examine the relation of electroencephalographic abnormalities to 5-year outcomes in first-episode psychosis (FEP).METHODS: Patients (n = 103) had their baseline electroencephalogram (EEG) classified by modified Mayo Clinic criteria. Symptoms and psychosocial functioning were rated after 5 years of treatment.RESULTS: Dysrhythmic EEG was associated with persistence in positive and negative symptoms of psychoses and poorer psychosocial functioning at 5-year follow-up, independently of other characteristics, such as duration of untreated illness or premorbid adjustment. A higher percentage of people with comorbid substance use disorder had normal EEG.CONCLUSIONS: Abnormal baseline EEG in FEP is associated with poorer 5-year symptomatic and functional outcome.

Alternate JournalCan J Psychiatry
PubMed ID25007282
PubMed Central IDPMC4079140
Grant ListMOP-57925 / / Canadian Institutes of Health Research / Canada