Effects of Genotype and Sleep on Temperament.

TitleEffects of Genotype and Sleep on Temperament.
Publication TypeJournal Article
Year of Publication2015
AuthorsBouvette-Turcot A-A, Pluess M, Bernier A, Pennestri M-H, Levitan R, Sokolowski MB, Kennedy JL, Minde K, Steiner M, Pokhvisneva I, Meaney MJ, Gaudreau H
Corporate AuthorsMAVAN Research Team
JournalPediatrics
Volume136
Issue4
Paginatione914-21
Date Published2015 Oct
ISSN1098-4275
KeywordsCanada, Child, Preschool, Cohort Studies, Female, Genotype, Humans, Infant, Longitudinal Studies, Male, Polymorphism, Genetic, Regression Analysis, Serotonin Plasma Membrane Transport Proteins, Sleep, Temperament
Abstract

BACKGROUND AND OBJECTIVES: Sleep problems are frequent in young children; however, children vary in the degree to which they are affected by poor sleep quality. We investigated whether a polymorphism in the serotonin transporter gene, which is linked to emotional function, is a potential moderator of the influences of sleep duration on infant temperament using longitudinal data.METHODS: We examined the interactive effects of average sleep duration between 6 and 36 months of age and the 5-HTTLPR genotype on negative emotionality/behavioral dysregulation at 36 months in 209 children recruited into a longitudinal birth cohort study. Triallelic genotyping of 5-HTTLPR was performed by looking at SLC6A4 genotype, focusing on the serotonin transporter-linked polymorphic region (5-HTTLPR) including the SNP polymorphism (rs23351). Child sleep habits were assessed with a maternal self-report questionnaire.RESULTS: After controlling for demographics and both previous and concurrent maternal depression, multiple linear regression analyses revealed a significant interaction effect of average sleep duration for the first 3 years of life and 5-HTTLPR genotype on child negative emotionality/behavioral dysregulation such that the effects were exclusive to those with low-expressing 5-HTTLPR genotypes.CONCLUSIONS: The results suggest differential susceptibility to the effect of sleep duration early in life, which reiterates that the short allele of the 5-HTTLPR represents a marker of increased environmental sensitivity regarding emotional development. Differential susceptibility theory posits that certain factors may increase an individual's susceptibility to the environment, in either a positive or negative fashion.

DOI10.1542/peds.2015-0080
Alternate JournalPediatrics
PubMed ID26371199
Grant List / / Canadian Institutes of Health Research / Canada

  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre