Early Environmental Upheaval and the Risk for Schizophrenia.

TitleEarly Environmental Upheaval and the Risk for Schizophrenia.
Publication TypeJournal Article
Year of Publication2021
AuthorsPaquin V, Lapierre M, Veru F, King S
JournalAnnu Rev Clin Psychol
Date Published2021 Feb 05
ISSN1548-5951
Abstract

Why does prenatal exposure to wars, natural disasters, urbanicity, or winter increase the risk for schizophrenia? Research from the last two decades has provided rich insight about the underlying chains of causation at play during environmental upheaval, from conception to early infancy. In this review, we appraise the evidence linking schizophrenia spectrum disorder to prenatal maternal stress, obstetric complications, early infections, and maternal nutrition and other lifestyle factors. We discuss putative mechanisms, including the maternal stress system, perinatal hypoxia, and maternal-offspring immune activation. We propose that gene-environment interactions, timing during development, and sex differentiate the neuropsychiatric outcomes. Future research should pursue the translation of animal studies to humans and the longitudinal associations between early exposures, intermediate phenotypes, and psychiatric disorders. Finally, to paint a comprehensive model of risk and to harness targets for prevention, we argue that risk factors should be situated within the individual's personal ecosystem. Expected final online publication date for the , Volume 17 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

DOI10.1146/annurev-clinpsy-081219-103805
Alternate JournalAnnu Rev Clin Psychol
PubMed ID33544627