Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions.

TitleDysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions.
Publication TypeJournal Article
Year of Publication2015
AuthorsKeshavan MS, Mehta UMeherwan, Padmanabhan JL, Shah JL
JournalDev Psychopathol
Volume27
Issue2
Pagination615-35
Date Published2015 May
ISSN1469-2198
KeywordsHumans, Neuronal Plasticity, Psychotic Disorders, Risk Factors, Schizophrenia, Schizophrenic Psychology
Abstract

In this paper, we review the history of the concept of neuroplasticity as it relates to the understanding of neuropsychiatric disorders, using schizophrenia as a case in point. We briefly review the myriad meanings of the term neuroplasticity, and its neuroscientific basis. We then review the evidence for aberrant neuroplasticity and metaplasticity associated with schizophrenia as well as the risk for developing this illness, and discuss the implications of such understanding for prevention and therapeutic interventions. We argue that the failure and/or altered timing of plasticity of critical brain circuits might underlie cognitive and deficit symptoms, and may also lead to aberrant plastic reorganization in other circuits, leading to affective dysregulation and eventually psychosis. This "dysplastic" model of schizophrenia can suggest testable etiology and treatment-relevant questions for the future.

DOI10.1017/S095457941500019X
Alternate JournalDev. Psychopathol.
PubMed ID25997775
Grant List92440 / / PHS HHS / United States
MH 60902 / MH / NIMH NIH HHS / United States

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