Diurnal cortisol and mental well-being in middle and older age: evidence from four cohort studies.
|Title||Diurnal cortisol and mental well-being in middle and older age: evidence from four cohort studies.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Stafford M, Ben-Shlomo Y, Cooper C, Gale C, Gardner MP, Geoffroy M-C, Power C, Kuh D, Cooper R|
|Date Published||2017 Oct 12|
OBJECTIVES: We conducted an individual participant meta-analysis to test the hypothesis that cortisol patterns indicative of dysregulated hypothalamic-pituitary-adrenal axis functioning would be prospectively associated with poorer well-being at follow-up.SETTING: Four large UK-based cohort studies.PARTICIPANTS: Those providing valid salivary or serum cortisol samples (n=7515 for morning cortisol; n=1612 for cortisol awakening response) at baseline (age 44-82) and well-being data on the Warwick Edinburgh Mental Wellbeing Scale at follow-up (0-8 years) were included.RESULTS: Well-being was not associated with morning cortisol, diurnal slope or awakening response though a borderline association with evening cortisol was found. Adjusting for sex and follow-up time, each 1 SD increase in evening cortisol was associated with a -0.47 (95% CI -1.00 to 0.05) point lower well-being. This was attenuated by adjustment for body mass index, smoking and socioeconomic position. Between-study heterogeneity was low.CONCLUSIONS: This study does not support the hypothesis that diurnal cortisol is prospectively associated with well-being up to 8 years later. However, replication in prospective studies with cortisol samples over multiple days is required.
|Alternate Journal||BMJ Open|
|PubMed Central ID||PMC5652457|
|Grant List||MC_U147585819 / / Medical Research Council / United Kingdom |
MC_UP_A620_1014 / / Medical Research Council / United Kingdom
MC_UU_12011/1 / / Medical Research Council / United Kingdom