Decreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicides.

TitleDecreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicides.
Publication TypeJournal Article
Year of Publication2015
AuthorsLutz P-E, Zhou Y, Labbe A, Mechawar N, Turecki G
JournalEur Neuropsychopharmacol
Volume25
Issue11
Pagination2008-14
Date Published2015 Nov
ISSN1873-7862
KeywordsAdult, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Opioid Peptides, Polymerase Chain Reaction, Protein Precursors, Receptors, Opioid, RNA, Messenger, Suicide, Thalamus
Abstract

The nociceptin/orphanin FQ (N/OFQ)-Nociceptin Opiod-like Peptide (NOP) receptor system is a critical mediator of physiological and pathological processes involved in emotional regulation and drug addiction. As such, this system may be an important biological substrate underlying psychiatric conditions that contribute to the risk of suicide. Thus, the goal of the present study was to characterize changes in human N/OFQ and NOP signaling as a function of depression, addiction and suicide. We quantified the expression of N/OFQ and NOP by RT-PCR in the anterior insula, the mediodorsal thalamus, and the dorsal anterior cingulate cortex (dACC) from a large sample of individuals who died by suicide and matched psychiatrically-healthy controls. Suicides displayed an 18% decrease in the expression of N/OFQ in the dACC that was not accounted for by current depressive or substance use disorders at the time of death. Therefore, our results suggest that dysregulation of the N/OFQ-NOP system may contribute to the neurobiology of suicide, a hypothesis that warrants further exploration.

DOI10.1016/j.euroneuro.2015.08.015
Alternate JournalEur Neuropsychopharmacol
PubMed ID26349406
PubMed Central IDPMC4655195
Grant ListMOP93775 / / Canadian Institutes of Health Research / Canada
1R01DA033684-01 / DA / NIDA NIH HHS / United States
MOP119430 / / Canadian Institutes of Health Research / Canada
R01 DA033684 / DA / NIDA NIH HHS / United States
MOP119429 / / Canadian Institutes of Health Research / Canada
MOP11260 / / Canadian Institutes of Health Research / Canada