dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.

Titledcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.
Publication TypeJournal Article
Year of Publication2013
AuthorsManitt C, Eng C, Pokinko M, Ryan RT, Torres-Berrío A, Lopez JP, Yogendran SV, Daubaras MJJ, Grant A, Schmidt ERE, Tronche F, Krimpenfort P, Cooper HM, Pasterkamp RJ, Kolb B, Turecki G, Wong TPan, Nestler EJ, Giros B, Flores C
JournalTransl Psychiatry
Date Published2013 Dec 17
KeywordsAdolescent, Adolescent Development, Animals, Case-Control Studies, Dopaminergic Neurons, Genes, DCC, Genetic Predisposition to Disease, Haploinsufficiency, Humans, Male, Mental Disorders, Mice, Neural Pathways, Prefrontal Cortex, Self-Injurious Behavior, Suicide

Adolescence is a period of heightened susceptibility to psychiatric disorders of medial prefrontal cortex (mPFC) dysfunction and cognitive impairment. mPFC dopamine (DA) projections reach maturity only in early adulthood, when their control over cognition becomes fully functional. The mechanisms governing this protracted and unique development are unknown. Here we identify dcc as the first DA neuron gene to regulate mPFC connectivity during adolescence and dissect the mechanisms involved. Reduction or loss of dcc from DA neurons by Cre-lox recombination increased mPFC DA innervation. Underlying this was the presence of ectopic DA fibers that normally innervate non-cortical targets. Altered DA input changed the anatomy and electrophysiology of mPFC circuits, leading to enhanced cognitive flexibility. All phenotypes only emerged in adulthood. Using viral Cre, we demonstrated that dcc organizes mPFC wiring specifically during adolescence. Variations in DCC may determine differential predisposition to mPFC disorders in humans. Indeed, DCC expression is elevated in brains of antidepressant-free subjects who committed suicide.

Alternate JournalTransl Psychiatry
PubMed ID24346136
PubMed Central IDPMC4030324
Grant ListP50 MH096890 / MH / NIMH NIH HHS / United States

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