Control of Rest:Activity by a Dopaminergic Ultradian Oscillator and the Circadian Clock.

TitleControl of Rest:Activity by a Dopaminergic Ultradian Oscillator and the Circadian Clock.
Publication TypeJournal Article
Year of Publication2017
AuthorsBourguignon C, Storch K-F
JournalFront Neurol
Volume8
Pagination614
Date Published2017
ISSN1664-2295
Abstract

There is long-standing evidence for rhythms in locomotor activity, as well as various other aspects of physiology, with periods substantially shorter than 24 h in organisms ranging from fruit flies to humans. These ultradian oscillations, whose periods frequently fall between 2 and 6 h, are normally well integrated with circadian rhythms; however, they often lack the period stability and expression robustness of the latter. An adaptive advantage of ultradian rhythms has been clearly demonstrated for the common vole, suggesting that they may have evolved to confer social synchrony. The cellular substrate and mechanism of ultradian rhythm generation have remained elusive so far, however recent findings-the subject of this review-now indicate that ultradian locomotor rhythms rely on an oscillator based on dopamine, dubbed the dopaminergic ultradian oscillator (DUO). These findings also reveal that the DUO period can be lengthened from <4 to >48 h by methamphetamine treatment, suggesting that the previously described methamphetamine-sensitive (circadian) oscillator represents a long-period manifestation of the DUO.

DOI10.3389/fneur.2017.00614
Alternate JournalFront Neurol
PubMed ID29230188
PubMed Central IDPMC5711773