Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET.

TitleCharacterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET.
Publication TypeJournal Article
Year of Publication2016
AuthorsDuBois JM, Rousset OG, Rowley J, Porras-Betancourt M, Reader AJ, Labbe A, Massarweh G, Soucy J-P, Rosa-Neto P, Kobayashi E
JournalEur J Nucl Med Mol Imaging
Volume43
Issue1
Pagination152-62
Date Published2016 Jan
ISSN1619-7089
KeywordsAdult, Aged, Aging, Brain, Carbon Radioisotopes, Female, Healthy Volunteers, Humans, Male, Middle Aged, Oximes, Positron-Emission Tomography, Pyridines, Receptor, Metabotropic Glutamate 5, Sex Characteristics, Young Adult
Abstract

PURPOSE: Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [(11)C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [(11)C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals.METHODS: Thirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [(11)C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere.RESULTS: We found the highest [(11)C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [(11)C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [(11)C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction.CONCLUSIONS: The present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.

DOI10.1007/s00259-015-3167-6
Alternate JournalEur. J. Nucl. Med. Mol. Imaging
PubMed ID26290423
Grant ListMOP-115131 / / Canadian Institutes of Health Research / Canada
MOP-93614 / / Canadian Institutes of Health Research / Canada

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