Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms.

TitleCardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms.
Publication TypeJournal Article
Year of Publication2018
AuthorsSchmitz N, Deschênes SS, Burns RJ, Danna SM, Franco OH, M Ikram A, Kivimäki M, Singh-Manoux A, Tiemeier H
JournalBr J Psychiatry
Volume212
Issue2
Pagination96-102
Date Published2018 Feb
ISSN1472-1465
Abstract

BACKGROUND: Previous studies have examined associations of cardiometabolic factors with depression and cognition separately. Aims To determine if depressive symptoms mediate the association between cardiometabolic factors and cognitive decline in two community studies.METHOD: Data for the analyses were drawn from the Rotterdam Study, the Netherlands (n = 2940) and the Whitehall II study, UK (n = 4469).RESULTS: Mediation analyses suggested a direct association between cardiometabolic factors and cognitive decline and an indirect association through depression: poorer cardiometabolic status at time 1 was associated with a higher level of depressive symptoms at time 2 (standardised regression coefficient 0.07 and 0.06, respectively), which, in turn, was associated with greater cognitive decline between time 2 and time 3 (standardised regression coefficient of -0.15 and -0.41, respectively).CONCLUSIONS: Evidence from two independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline. Declaration of interest None.

DOI10.1192/bjp.2017.26
Alternate JournalBr J Psychiatry
PubMed ID29436332