Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?

TitleAre Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?
Publication TypeJournal Article
Year of Publication2020
AuthorsDelorme TC, Srivastava LK, Cermakian N
JournalJ Biol Rhythms
Volume35
Issue4
Pagination325-339
Date Published2020 08
ISSN1552-4531
Abstract

Schizophrenia is a multifactorial disorder caused by a combination of genetic variations and exposure to environmental insults. Sleep and circadian rhythm disturbances are a prominent and ubiquitous feature of many psychiatric disorders, including schizophrenia. There is growing interest in uncovering the mechanistic link between schizophrenia and circadian rhythms, which may directly affect disorder outcomes. In this review, we explore the interaction between schizophrenia and circadian rhythms from 2 complementary angles. First, we review evidence that sleep and circadian rhythm disturbances constitute a fundamental component of schizophrenia, as supported by both human studies and animal models with genetic mutations related to schizophrenia. Second, we discuss the idea that circadian rhythm disruption interacts with existing risk factors for schizophrenia to promote schizophrenia-relevant behavioral and neurobiological abnormalities. Understanding the mechanistic link between schizophrenia and circadian rhythms will have implications for mitigating risk to the disorder and informing the development of circadian-based therapies.

DOI10.1177/0748730420929448
Alternate JournalJ Biol Rhythms
PubMed ID32498652
Grant ListPJT-153299 / / CIHR / Canada