[(18)F]FDG PET signal is driven by astroglial glutamate transport.

Title[(18)F]FDG PET signal is driven by astroglial glutamate transport.
Publication TypeJournal Article
Year of Publication2017
AuthorsZimmer ER, Parent MJ, Souza DG, Leuzy A, Lecrux C, Kim H-I, Gauthier S, Pellerin L, Hamel E, Rosa-Neto P
JournalNat Neurosci
Date Published2017 Mar

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [(18)F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [(18)F]FDG signal.

Alternate JournalNat. Neurosci.
PubMed ID28135241
PubMed Central IDPMC5378483