[(18)F]FDG PET signal is driven by astroglial glutamate transport.

Title[(18)F]FDG PET signal is driven by astroglial glutamate transport.
Publication TypeJournal Article
Year of Publication2017
AuthorsZimmer ER, Parent MJ, Souza DG, Leuzy A, Lecrux C, Kim H-I, Gauthier S, Pellerin L, Hamel E, Rosa-Neto P
JournalNat Neurosci
Volume20
Issue3
Pagination393-395
Date Published2017 Mar
ISSN1546-1726
Abstract

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [(18)F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [(18)F]FDG signal.

DOI10.1038/nn.4492
Alternate JournalNat. Neurosci.
PubMed ID28135241
PubMed Central IDPMC5378483