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Yang Xiao

2024-05-13 @ 11:00 - 12:00 EDT

Please join us for a Special Neuroscience Seminar on May 13, 2024.


Dr. Yang Xiao, PhD
Postdoctoral Researcher Department of Biomedical Engineering,
Columbia University



Spatial Omic Mapping of Human Brain Disorders


Spatial proteomics, transcriptomics, and epigenomics are emerging to bring unprecedented opportunities to dissecting cell types and unraveling regulatory mechanisms of cell states within complex tissues. Despite the human hippocampus being critical for memory and emotion, and its implication in neuropsychiatric disorders, understanding its molecular dysfunction with spatial architecture has been challenging. Our engineering innovation in the spatial mRNA-seq and ATAC-seq platform (DBiT-seq) resulted in the presentation of the first spatial omic atlas of the human hippocampus. Combining with a 25-plex spatial proteomics profiled by CODEX, we introduced a computational framework for studying psychiatric diseases from the perspectives of cell neighborhoods and RNA velocity. This work reveals RNA dynamics in depression, highlighting therapeutic avenues by targeting gene regulatory networks. Our research represents a major leap in the field beyond the single-cell genomic studies of the human brain, establishing a corner stone for future molecular profiling studies with region and organization specific precision.


How to attend

This is a hybrid talk.

  • In person, at the Bowerman Room, Douglas Institute
  • Broadcast by Zoom

Meeting ID : 918 9333 5776

Password : 037442


Event Poster


11:00 - 12:00 EDT
Event Category:


Bowerman Room, Dobell Pavilion, Douglas Institute
6875 boul. LaSalle
Montreal, Quebec H4H 1R3 Canada
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