Antonio Marcus Paes

Please join us on Friday, May 5, 2023, at 11:00 AM, for Special Seminar hosted by the Environmental Adversity, Neurodevelopment and Mental Health theme-based group

Speaker

Antonio Marcus Paes
Professor, Human Physiology, Federal University of Maranhão, Brazil
Principal Investigator, Health Sciences Graduate Program
President, Latin American DOHaD Chapter

Title

Sugar deadly: Life course consequences of early-in-life exposure to dietary added sugars

Speaker Biography

Professor Paes has a Bachelor in Pharmaceutical Sciences by Federal University of Maranhão (Brazil, 1996), a Master in Cell Biology by the State University of Maringá (Brazil, 2000), and a PhD in Cardiology by the Hearth Institute, University of São Paulo (Brazil, 2009). Prof. Paes is an Associate Professor of Human Physiology at Federal University of Maranhão, where besides teaching duties he is a principal investigator at the Health Sciences Graduate Program. His main line of research entails the pathophysiology of metabolic syndrome-related disorders in intra- and intergenerational contexts, having generated 40+ peer-reviewed publications over the last 10 years. Last but not least, he is the current president of the Latin American DOHaD Chapter.

Abstract

The theory of the developmental origins of health and disease has been consistently recognized as an important contributor to the worldwide epidemic of obesity, metabolic syndrome, and their associated comorbidities. Although originally focused on the outcomes of maternal under- or over-nutrition during pregnancy, a body of evidence supports that diverse preconceptual, pregnancy and childhood exposures to environmental and nutritional stressors also contribute to developmental programming. Comorbidities associated with metabolic syndrome have also increased globally in children, being linked to higher consumption of sugar-enriched foods, which account to nearly 25% of the total energy daily intake in childhood. Notwithstanding, in developing countries, such as Brazil, Chile, and Mexico, over 60% of their population have been reported to consume excessive amounts of added sugars, particularly fructose and sucrose. However, differently from high-fat consumption, the molecular and biochemical mechanisms underlying the metabolic disorders induced by excess added sugars intake are still barely known. Thus, in this lecture, Prof. Paes will present a body of pre-clinical data generated by his laboratory over the last 10 years on how the early introduction of a sucrose-rich diet negatively impacts metabolic homeostasis of males, females, and their offspring.

Location

Live, in the Douglas Hall

Unable to attend?

For those of you who cannot make it in person, the talk will be broadcast via Zoom.