Agneta Nordberg

Please join us on Wednesday, June 16, 2021, at 10 am for the next talk in the International Dementia Conference Series,  hosted by the McGill Centre for Studies in Aging.
 

Reactive astrogliosis at different stages of Alzheimer’s disease –relationship with other pathology biomarkers and clinical implications

Speaker: Dr. Agneta Nordberg
Professor
H1 Department of Neurobiology, Care Sciences and Society
Karolinska Institutet, Solna, Sweden

Talk description: 
Astrocytes are well known to play an important role in the optimal functioning of the brain including regulating the synapse function. The astrocytes respond to changes in brain homoeostasis by a defence process named reactive astrogliosis, which is observed in AD as well in other neurodegenerative disorders. Reactive astrocytes are closely related to amyloid plaque and tau deposition in AD and more recently new data suggest that reactive astrogliosis in the early time course of AD may precede other pathological hallmarks of AD.  Translational in vivo /in vitro tracer imaging studies suggest ” a first and a second wave” of the reactive astrogliosis in AD with different relationship with other AD pathology biomarkers at the different stages of the disease. Several new PET tracers for visualizing reactive astrogliosis in brain will provide further valuable insight to disease mechanisms for both AD and other non-AD dementia.  The clinical value of new fluid astrocytes biomarkers is a new avenue to be explored. 

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Meeting ID: 849 3039 3051
Passcode: 584537