Epistatic interactions involving DRD2, DRD4, and COMT polymorphisms and risk of substance abuse in women with binge-purge eating disturbances.

TitleEpistatic interactions involving DRD2, DRD4, and COMT polymorphisms and risk of substance abuse in women with binge-purge eating disturbances.
Publication TypeJournal Article
Year of Publication2016
AuthorsSteiger H, Thaler L, Gauvin L, Joober R, Labbe A, Israel M, Kucer A
JournalJ Psychiatr Res
Volume77
Pagination8-14
Date Published2016 Jun
ISSN1879-1379
KeywordsAdolescent, Adult, Bulimia Nervosa, Catechol O-Methyltransferase, Epistasis, Genetic, Female, Genetic Predisposition to Disease, Genotyping Techniques, Humans, Middle Aged, Polymorphism, Genetic, Receptors, Dopamine D2, Receptors, Dopamine D4, Regression Analysis, Risk, Substance-Related Disorders, Young Adult
Abstract

Substance abuse is common in individuals with bulimia-spectrum (binge-purge) eating disturbances, a co-occurrence that has been attributed to shared neurobiological substrates--notably alterations in dopaminergic activity. We examined the implications of variations of selected, dopamine-relevant polymorphisms (DRD2 Taq1A, DRD4 7R, and COMT) for risk of substance abuse in women with binge-purge eating syndromes. We genotyped 183 women (66.1% showing full-threshold BN and 33.9% showing sub-syndromic variants), and assessed lifetime presence of alcohol, cannabis, cocaine, and stimulant abuse or dependence using structured interviews. Tests for main and interaction effects of various allele combinations revealed that individuals who carried high function COMT and low-function DRD4 7R alleles (a combination expected to be associated with higher risk) did indeed show more lifetime substance abuse and, specifically, more cannabis abuse. Our findings suggest that a gene combination that, in theory, codes for low levels of dopaminergic neurotransmission coincides with sensitivity to substance abuse in a sample displaying binge-purge eating-disorder variants.

DOI10.1016/j.jpsychires.2016.02.011
Alternate JournalJ Psychiatr Res
PubMed ID26950642
Grant ListMOP-57929 / / Canadian Institutes of Health Research / Canada
MOP-79490 / / Canadian Institutes of Health Research / Canada