by Epistatic Interaction in Modulating Behaviors in Children with ADHD: A Pharmaco-Dynamic Behavioral Approach.

Title by Epistatic Interaction in Modulating Behaviors in Children with ADHD: A Pharmaco-Dynamic Behavioral Approach.
Publication TypeJournal Article
Year of Publication2020
AuthorsFageera W, Grizenko N, Sengupta SM, Schmitz N, Joober R
JournalJ Atten Disord
Pagination1087054720934191
Date Published2020 Jun 20
ISSN1557-1246
Abstract

OBJECTIVE: Examining the joint effect of two functional variants in two dopamine-related genes ( and ) on ADHD-relevant behaviors under three experimental conditions (EC).METHOD: 362 children with ADHD were assessed by parents and teachers during a week of baseline evaluation, followed by 1 week of MPH and placebo, administered in a double-blind crossover design.RESULTS: Statistically significant 3-way (-by--by-EC; = .004) and 2-way interactions ( by EC; = .002) were observed on Conners'-Teachers scores. Children with the Met/Met genotype had lower scores at baseline and on placebo compared to the other genotype groups. Furthermore, stratifying the children according to their genotypes helped to detect statistically significant and biologically meaningful effects of genotype.CONCLUSIONS: These findings suggest that and genetic variants may together play a role in ADHD symptomatology and response to treatment through gene-gene interaction.

DOI10.1177/1087054720934191
Alternate JournalJ Atten Disord
PubMed ID32564645