by Epistatic Interaction in Modulating Behaviors in Children with ADHD: A Pharmaco-Dynamic Behavioral Approach.
|Title||by Epistatic Interaction in Modulating Behaviors in Children with ADHD: A Pharmaco-Dynamic Behavioral Approach.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Fageera W, Grizenko N, Sengupta SM, Schmitz N, Joober R|
|Journal||J Atten Disord|
|Date Published||2020 Jun 20|
OBJECTIVE: Examining the joint effect of two functional variants in two dopamine-related genes ( and ) on ADHD-relevant behaviors under three experimental conditions (EC).METHOD: 362 children with ADHD were assessed by parents and teachers during a week of baseline evaluation, followed by 1 week of MPH and placebo, administered in a double-blind crossover design.RESULTS: Statistically significant 3-way (-by--by-EC; = .004) and 2-way interactions ( by EC; = .002) were observed on Conners'-Teachers scores. Children with the Met/Met genotype had lower scores at baseline and on placebo compared to the other genotype groups. Furthermore, stratifying the children according to their genotypes helped to detect statistically significant and biologically meaningful effects of genotype.CONCLUSIONS: These findings suggest that and genetic variants may together play a role in ADHD symptomatology and response to treatment through gene-gene interaction.
|Alternate Journal||J Atten Disord|