The Epigenetics of Early Life Adversity: Current Limitations and Possible Solutions.

TitleThe Epigenetics of Early Life Adversity: Current Limitations and Possible Solutions.
Publication TypeJournal Article
Year of Publication2018
AuthorsBurns SBarnett, Almeida D, Turecki G
JournalProg Mol Biol Transl Sci
Volume157
Pagination343-425
Date Published2018
ISSN1878-0814
Abstract

Adverse experiences during sensitive postnatal developmental periods can disrupt the calibration of fundamental systems and increase the risk of a wide range of adult disease states, including psychiatric illnesses. Accumulating evidence suggests that epigenetic modifications involving DNA methylation, posttranslational histone modifications, and noncoding RNAs may be a key mediating factor in this disruption. Accumulating evidence from both animal models and human studies suggests that early life adversity alters the epigenome at multiple loci across the genome, but that the specific alterations, and the associated transcriptomic and psychiatric outcomes may be dependent on multiple individual factors. Here we will review the current findings on early life adversity associated alterations of the epigenome in animal models and humans, discuss current limitations, and highlight possible solutions and future directions.

DOI10.1016/bs.pmbts.2018.01.008
Alternate JournalProg Mol Biol Transl Sci
PubMed ID29933955