The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.

TitleThe ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
Publication TypeJournal Article
Year of Publication2014
AuthorsThompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AArias, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B et al.
Corporate AuthorsAlzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study(SYS) Group
JournalBrain Imaging Behav
Volume8
Issue2
Pagination153-82
Date Published2014 Jun
ISSN1931-7565
KeywordsBrain Mapping, Cooperative Behavior, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Neuroimaging
Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

DOI10.1007/s11682-013-9269-5
Alternate JournalBrain Imaging Behav
PubMed ID24399358
PubMed Central IDPMC4008818
Grant List100309 / / Wellcome Trust / United Kingdom
104036 / / Wellcome Trust / United Kingdom
BB/F019394/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
G-0907 / / Parkinson's UK / United Kingdom
G0700704 / / Medical Research Council / United Kingdom
G0701120 / / Medical Research Council / United Kingdom
G0802462 / / Medical Research Council / United Kingdom
G0901254 / / Medical Research Council / United Kingdom
G1001245 / / Medical Research Council / United Kingdom
K01 MH099232 / MH / NIMH NIH HHS / United States
K99 LM011384 / LM / NLM NIH HHS / United States
K99 MH101367 / MH / NIMH NIH HHS / United States
MR/J006742/1 / / Medical Research Council / United Kingdom
MR/K01417X/1 / / Medical Research Council / United Kingdom
MR/K026992/1 / / Medical Research Council / United Kingdom
P30 AG010133 / AG / NIA NIH HHS / United States
P41 EB015922 / EB / NIBIB NIH HHS / United States
P50 AG005134 / AG / NIA NIH HHS / United States
R00 LM011384 / LM / NLM NIH HHS / United States
R01 AG019771 / AG / NIA NIH HHS / United States
R01 AG040770 / AG / NIA NIH HHS / United States
R01 EB005846 / EB / NIBIB NIH HHS / United States
R01 EB015611 / EB / NIBIB NIH HHS / United States
R01 LM011360 / LM / NLM NIH HHS / United States
U01 AG024904 / AG / NIA NIH HHS / United States
U24 AG021886 / AG / NIA NIH HHS / United States

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