The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report.

TitleThe Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report.
Publication TypeJournal Article
Year of Publication2017
AuthorsChung JKu, Plitman E, Nakajima S, Caravaggio F, Shinagawa S, Iwata Y, Gerretsen P, Kim J, Takeuchi H, Patel R, M Chakravarty M, Strafella A, Graff-Guerrero A
Corporate AuthorsAlzheimer’s Disease Neuroimaging Initiative
JournalJ Alzheimers Dis
Volume60
Issue2
Pagination341-347
Date Published2017
ISSN1875-8908
Abstract

The clinical and structural trajectories of suspected non-Alzheimer' pathology (SNAP) remain elusive due to its heterogeneous etiology. Baseline and longitudinal clinical (global cognition, daily functioning, symptoms of dementia, and learning memory) and hippocampal volume trajectories over two years were compared between patients with amnestic mild cognitive impairment (aMCI) with SNAP with reduced hippocampal volumes (SNAP+HIPPO) and aMCI patients with SNAP without reduced hippocampal volumes. SNAP+HIPPO showed overall worse baseline cognitive functions. Longitudinally, SNAP+HIPPO showed faster deterioration of clinical symptoms of dementia. Having both hippocampal atrophy and cortical hypometabolism without amyloid pathology may exacerbate symptoms of dementia in aMCI.

DOI10.3233/JAD-170098
Alternate JournalJ. Alzheimers Dis.
PubMed ID28826178