During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run.

TitleDuring Running in Place, Grid Cells Integrate Elapsed Time and Distance Run.
Publication TypeJournal Article
Year of Publication2015
AuthorsKraus BJ, Brandon MP, Robinson RJ, Connerney MA, Hasselmo ME, Eichenbaum H
JournalNeuron
Volume88
Issue3
Pagination578-89
Date Published2015 Nov 04
ISSN1097-4199
KeywordsAction Potentials, Animals, Electrodes, Implanted, Entorhinal Cortex, Exercise Test, Male, Rats, Rats, Long-Evans, Running, Time Factors
Abstract

The spatial scale of grid cells may be provided by self-generated motion information or by external sensory information from environmental cues. To determine whether grid cell activity reflects distance traveled or elapsed time independent of external information, we recorded grid cells as animals ran in place on a treadmill. Grid cell activity was only weakly influenced by location, but most grid cells and other neurons recorded from the same electrodes strongly signaled a combination of distance and time, with some signaling only distance or time. Grid cells were more sharply tuned to time and distance than non-grid cells. Many grid cells exhibited multiple firing fields during treadmill running, parallel to the periodic firing fields observed in open fields, suggesting a common mode of information processing. These observations indicate that, in the absence of external dynamic cues, grid cells integrate self-generated distance and time information to encode a representation of experience.

DOI10.1016/j.neuron.2015.09.031
Alternate JournalNeuron
PubMed ID26539893
PubMed Central IDPMC4635558
Grant ListMH095297 / MH / NIMH NIH HHS / United States
R01 MH095297 / MH / NIMH NIH HHS / United States
MH071702 / MH / NIMH NIH HHS / United States
R01 MH060013 / MH / NIMH NIH HHS / United States
P50 MH071702 / MH / NIMH NIH HHS / United States
MH060013 / MH / NIMH NIH HHS / United States