DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects.

TitleDNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects.
Publication TypeJournal Article
Year of Publication2017
AuthorsVaillancourt K, Ernst C, Mash D, Turecki G
JournalGenes (Basel)
Volume8
Issue5
Date Published2017 May 12
ISSN2073-4425
Abstract

Cytosine modifications, including DNA methylation, are stable epigenetic marks that may translate environmental change into transcriptional regulation. Research has begun to investigate DNA methylation dynamics in relation to cocaine use disorders. Specifically, DNA methylation machinery, including methyltransferases and binding proteins, are dysregulated in brain reward pathways after chronic cocaine exposure. In addition, numerous methylome-wide and candidate promoter studies have identified differential methylation, at the nucleotide level, in rodent models of cocaine abuse and drug seeking behavior. This review highlights the current progress in the field of cocaine-related methylation, and offers considerations for future research.

DOI10.3390/genes8050138
Alternate JournalGenes (Basel)
PubMed ID28498318
PubMed Central IDPMC5448012