DNA methylation and childhood maltreatment: from animal models to human studies.
|Title||DNA methylation and childhood maltreatment: from animal models to human studies.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Lutz P-E, Turecki G|
|Date Published||2014 Apr 4|
|Keywords||Age of Onset, Animals, Brain, Child, Child Abuse, DNA Methylation, Epigenesis, Genetic, Female, Humans, Male, Mental Disorders, Mice, Models, Animal, Rats, Stress, Psychological|
Childhood maltreatment (CM) has estimated prevalence among Western societies between 10% and 15%. As CM associates with increased risk of several psychiatric disorders, early age of illness onset, increased comorbidity and negative clinical outcome, it imposes a major public health, social and economic impact. Although the clinical consequences of CM are well characterized, a major challenge remains to understand how negative early-life events can affect brain function over extended periods of time. We review here both animal and human studies indicating that the epigenetic mechanism of DNA methylation is a crucial mediator of early-life experiences, thereby maintaining life-long neurobiological sequelae of CM, and strongly determining psychopathological risk.