Disrupted prefrontal interhemispheric structural coupling in schizophrenia related to working memory performance.

TitleDisrupted prefrontal interhemispheric structural coupling in schizophrenia related to working memory performance.
Publication TypeJournal Article
Year of Publication2014
AuthorsWheeler AL, M Chakravarty M, Lerch JP, Pipitone J, Daskalakis ZJ, Rajji TK, Mulsant BH, Voineskos AN
JournalSchizophr Bull
Volume40
Issue4
Pagination914-24
Date Published2014 Jul
ISSN1745-1701
KeywordsAdult, Brain, Case-Control Studies, Cognition Disorders, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Organ Size, Prefrontal Cortex, Schizophrenia, Schizophrenic Psychology, Temporal Lobe, Young Adult
Abstract

BACKGROUND: Prominent regional cortical thickness reductions have been shown in schizophrenia. In contrast, little is known regarding alterations of structural coupling between regions in schizophrenia and how these alterations may be related to cognitive impairments in this disorder.METHODS: T1-weighted magnetic resonance images were acquired in 54 patients with schizophrenia and 68 healthy control subjects aged 18-55 years. Cortical thickness was compared between groups using a vertex-wise approach. To assess structural coupling, seeds were selected within regions of reduced thickness, and brain-wide cortical thickness correlations were compared between groups. The relationships between identified patterns of circuit structure disruption and cognitive task performance were then explored.RESULTS: Prominent cortical thickness reductions were found in patients compared with controls at a 5% false discovery rate in a predominantly frontal and temporal pattern. Correlations of the left dorsolateral prefrontal cortex (DLPFC) with right prefrontal regions were significantly different in patients and controls. The difference remained significant in a subset of 20 first-episode patients. Participants with stronger frontal interhemispheric thickness correlations had poorer working memory performance.CONCLUSIONS: We identified structural impairment in a left-right DLPFC circuit in patients with schizophrenia independent of illness stage or medication exposure. The relationship between left-right DLPFC thickness correlations and working memory performance implicates prefrontal interhemispheric circuit impairment as a vulnerability pathway for poor working memory performance. Our findings could guide the development of novel therapeutic interventions aimed at improving working memory performance in patients with schizophrenia.

DOI10.1093/schbul/sbt100
Alternate JournalSchizophr Bull
PubMed ID23873858
PubMed Central IDPMC4059434
Grant ListR01MH099167 / MH / NIMH NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada

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