Development of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase.

TitleDevelopment of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase.
Publication TypeJournal Article
Year of Publication2016
AuthorsGordon MForrest, Lenderking WR, Duhig A, Chandler J, J Lundy J, Miller DS, Piault-Louis E, Doody RS, Galasko D, Gauthier S, Frank L
Corporate AuthorsPatient-Reported Outcome Consortium's Cognition Working Group
JournalAlzheimers Dement
Volume12
Issue1
Pagination75-84
Date Published2016 Jan
ISSN1552-5279
KeywordsActivities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Cognitive Dysfunction, Female, Humans, Interpersonal Relations, Male, Middle Aged, Neuropsychological Tests, Patient Outcome Assessment, Qualitative Research, Self Report
Abstract

INTRODUCTION: As drug development research efforts move toward studying patients earlier in the course of Alzheimer's disease (AD), it is important to incorporate the patient's perspective into measurement of outcomes.METHODS: This article summarizes the qualitative work of the Patient-Reported Outcome Consortium's Cognition Working Group in the development of a new self-reported outcome measure in persons with mild cognitive impairment (MCI) due to suspected AD, herein referred to as MCI.RESULTS: The draft measure captures the patient's voice for two functional domains, complex activities of daily living and interpersonal functioning.DISCUSSION: This work represents a series of initial steps in the development of this rating scale. The next steps are to conduct psychometric analysis and evaluate the role of insight.

DOI10.1016/j.jalz.2015.04.008
Alternate JournalAlzheimers Dement
PubMed ID26079412

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