Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.

TitleDelphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.
Publication TypeJournal Article
Year of Publication2015
AuthorsBoccardi M, Bocchetta M, Apostolova LG, Barnes J, Bartzokis G, Corbetta G, DeCarli C, deToledo-Morrell L, Firbank M, Ganzola R, Gerritsen L, Henneman W, Killiany RJ, Malykhin N, Pasqualetti P, Pruessner JC, Redolfi A, Robitaille N, Soininen H, Tolomeo D, Wang L, Watson C, Wolf H, Duvernoy H, Duchesne S, Jack CR, Frisoni GB
Corporate AuthorsSegmentation E-AWorking Gr
JournalAlzheimers Dement
Volume11
Issue2
Pagination126-38
Date Published2015 Feb
ISSN1552-5279
KeywordsAlzheimer Disease, Atrophy, Consensus, Delphi Technique, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internationality, Magnetic Resonance Imaging, Neuroimaging
Abstract

BACKGROUND: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.METHODS: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.RESULTS: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DISCUSSION: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

DOI10.1016/j.jalz.2014.02.009
Alternate JournalAlzheimers Dement
PubMed ID25130658
PubMed Central IDPMC4419736
Grant ListP30 AG010129 / AG / NIA NIH HHS / United States