Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.
|Title||Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Boccardi M, Bocchetta M, Apostolova LG, Barnes J, Bartzokis G, Corbetta G, DeCarli C, deToledo-Morrell L, Firbank M, Ganzola R, Gerritsen L, Henneman W, Killiany RJ, Malykhin N, Pasqualetti P, Pruessner JC, Redolfi A, Robitaille N, Soininen H, Tolomeo D, Wang L, Watson C, Wolf H, Duvernoy H, Duchesne S, Jack CR, Frisoni GB|
|Corporate Authors||Segmentation E-AWorking Gr|
|Date Published||2015 Feb|
|Keywords||Alzheimer Disease, Atrophy, Consensus, Delphi Technique, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internationality, Magnetic Resonance Imaging, Neuroimaging|
BACKGROUND: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.METHODS: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.RESULTS: Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DISCUSSION: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.
|Alternate Journal||Alzheimers Dement|
|PubMed Central ID||PMC4419736|
|Grant List||P30 AG010129 / AG / NIA NIH HHS / United States|