Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms.

TitleCortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms.
Publication TypeJournal Article
Year of Publication2014
AuthorsBodnar M, Hovington CL, Buchy L, Malla A, Joober R, Lepage M
JournalPLoS One
Volume9
Issue6
Paginatione101372
Date Published2014
ISSN1932-6203
KeywordsAdolescent, Adult, Female, Humans, Magnetic Resonance Imaging, Male, Parietal Lobe, Psychotic Disorders, Temporal Lobe
Abstract

BACKGROUND: Negative symptoms represent an unmet therapeutic need in many patients with schizophrenia. In an extension to our previous voxel-based morphometry findings, we employed a more specific, vertex-based approach to explore cortical thinning in relation to persistent negative symptoms (PNS) in non-affective first-episode of psychosis (FEP) patients to advance our understanding of the pathophysiology of primary negative symptoms.METHODS: This study included 62 non-affective FEP patients and 60 non-clinical controls; 16 patients were identified with PNS (i.e., at least 1 primary negative symptom at moderate or greater severity sustained for at least 6 consecutive months). Using cortical thickness analyses, we explored for differences between PNS and non-PNS patients as well as between each patient group and healthy controls; cut-off threshold was set at p<0.01, corrected for multiple comparisons.RESULTS: A thinner cortex prominently in the right superior temporal gyrus extending into the temporo-parietal junction (TPJ), right parahippocampal gyrus, and left orbital frontal gyrus was identified in PNS patients vs. non-PNS patients. Compared with healthy controls, PNS patients showed a thinner cortex prominently in the right superior temporal gyrus, right parahippocampal gyrus, and right cingulate; non-PNS patients showed a thinner cortex prominently in the parahippocampal gyrus bi-laterally.CONCLUSION: Cortical thinning in the early stages of non-affective psychosis is present in the frontal and temporo-parietal regions in patients with PNS. With these brain regions strongly related to social cognitive functioning, our finding suggests a potential link between primary negative symptoms and social cognitive deficits through common brain etiologies.

DOI10.1371/journal.pone.0101372
Alternate JournalPLoS ONE
PubMed ID24979583
PubMed Central IDPMC4076331
Grant List68961 / / Canadian Institutes of Health Research / Canada


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