Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence.

TitleContribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence.
Publication TypeJournal Article
Year of Publication2019
AuthorsOrri M, Geoffroy M-C, Turecki G, Feng B, Brendgen M, Vitaro F, Dionne G, Paquin S, Galera C, Renaud J, Tremblay RE, Côté SM, Boivin M
JournalJ Child Psychol Psychiatry
Date Published2019 Nov 28
ISSN1469-7610
Abstract

BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood.METHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components.RESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027.CONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention.

DOI10.1111/jcpp.13163
Alternate JournalJ Child Psychol Psychiatry
PubMed ID31782164
Grant List410-2001-1475 / / Social Science and Humanities Research Council (SSHRC) /
435-2014-1536 / / Social Science and Humanities Research Council (SSHRC) /
793396 / / European Union's Horizon 2020 /
/ / American Foundation for Suicide Prevention /
FDN148374 / / Canadian Institute of Health Research (CIHR) /
EGM141899 / / Canadian Institute of Health Research (CIHR) /
/ / Fonds de recherche du Québec - Santé (FRQS) /