Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.

TitleConjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.
Publication TypeJournal Article
Year of Publication2021
Authorsvan der Veldt S, Etter G, Mosser C-A, Manseau F, Williams S
JournalPLoS Biol
Volume19
Issue8
Paginatione3001383
Date Published2021 08
ISSN1545-7885
KeywordsAnimals, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Female, GABAergic Neurons, Male, Mice, Septum of Brain, Spatial Memory
Abstract

The hippocampal spatial code's relevance for downstream neuronal populations-particularly its major subcortical output the lateral septum (LS)-is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared the spatial tuning of LS GABAergic cells to those of dorsal CA3 and CA1 cells. We identified a significant number of LS cells that are modulated by place, speed, acceleration, and direction, as well as conjunctions of these properties, directly comparable to hippocampal CA1 and CA3 spatially modulated cells. Interestingly, Bayesian decoding of position based on LS spatial cells reflected the animal's location as accurately as decoding using the activity of hippocampal pyramidal cells. A portion of LS cells showed stable spatial codes over the course of multiple days, potentially reflecting long-term episodic memory. The distributions of cells exhibiting these properties formed gradients along the anterior-posterior and dorsal-ventral axes of the LS, directly reflecting the topographical organization of hippocampal inputs to the LS. Finally, we show using transsynaptic tracing that LS neurons receiving CA3 and CA1 excitatory input send projections to the hypothalamus and medial septum, regions that are not targeted directly by principal cells of the dorsal hippocampus. Together, our findings demonstrate that the LS accurately and robustly represents spatial, directional as well as self-motion information and is uniquely positioned to relay this information from the hippocampus to its downstream regions, thus occupying a key position within a distributed spatial memory network.

DOI10.1371/journal.pbio.3001383
Alternate JournalPLoS Biol
PubMed ID34460812
PubMed Central IDPMC8432898