Comparative analysis of self-injury in people with psychopathology or neurodevelopmental disorders.

TitleComparative analysis of self-injury in people with psychopathology or neurodevelopmental disorders.
Publication TypeJournal Article
Year of Publication2015
AuthorsCrapper L, Ernst C
JournalPediatr Clin North Am
Volume62
Issue3
Pagination619-31
Date Published2015 Jun
ISSN1557-8240
KeywordsChild, Developmental Disabilities, Humans, Mental Disorders, Prevalence, Risk Factors, Self-Injurious Behavior
Abstract

Self-injury is a complex and poorly understood behavior observed in people with psychopathology or neurodevelopmental disorders (NDD). Despite the differences in etiology and progression of these distinct disease domains, it is possible that overlapping molecular pathways underlie the expression of self-injurious behaviors (SIBs). This review outlines the similarities and differences at the behavioural and molecular level, where SIBs in both conditions may involve opioid, nucleoside, and dopamine signalling. These points of convergence have important implications for treatment and research of SIB in both populations.

DOI10.1016/j.pcl.2015.03.001
Alternate JournalPediatr. Clin. North Am.
PubMed ID26022166

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