Cognitive insight in first-episode schizophrenia: further evidence for a role of the ventrolateral prefrontal cortex.

TitleCognitive insight in first-episode schizophrenia: further evidence for a role of the ventrolateral prefrontal cortex.
Publication TypeJournal Article
Year of Publication2015
AuthorsBuchy L, Hawco C, Joober R, Malla A, Lepage M
JournalSchizophr Res
Volume166
Issue1-3
Pagination65-8
Date Published2015 Aug
ISSN1573-2509
KeywordsBrain Mapping, Cognition, Female, Humans, Judgment, Magnetic Resonance Imaging, Male, Memory, Neuropsychological Tests, Prefrontal Cortex, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Self Concept, Young Adult
Abstract

In people with psychoses, Self-Reflectiveness may rely on the right ventrolateral prefrontal cortex (VLPFC). We used functional magnetic resonance imaging (fMRI) and a novel virtual reality paradigm to evaluate the role of the VLPFC for Self-Reflectiveness in 25 first-episode of schizophrenia (FES) participants and 24 controls. Participants first viewed 20 characters each paired with a unique object/location, and later completed source memory judgements during fMRI scanning. Self-Reflectiveness, measured with the Beck Cognitive Insight Scale, was significantly and positively correlated to activation in bilateral VLPFC in FES, but not in controls, providing further evidence that the VLPFC supports Self-Reflectiveness in FES.

DOI10.1016/j.schres.2015.05.009
Alternate JournalSchizophr. Res.
PubMed ID26004692
Grant List68961 / / Canadian Institutes of Health Research / Canada

McGill Logo

CIUSSS ouest montreal logo

 



  • Douglas Hospital
  • Dobell Pavillion
  • Brain imaging centre