Co-bedding between preterm twins attenuates stress response after heel lance: results of a randomized trial.
Title | Co-bedding between preterm twins attenuates stress response after heel lance: results of a randomized trial. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Campbell-Yeo ML, C Johnston C, Joseph KS, Feeley N, Chambers CT, Barrington KJ, C-D Walker |
Journal | Clin J Pain |
Volume | 30 |
Issue | 7 |
Pagination | 598-604 |
Date Published | 2014 Jul |
ISSN | 1536-5409 |
Keywords | Blood Specimen Collection, Female, Gestational Age, Heel, Humans, Hydrocortisone, Infant, Infant Care, Male, Premature Birth, Retrospective Studies, Saliva, Statistics, Nonparametric, Stress, Psychological |
Abstract | OBJECTIVE: To examine the effect of co-bedding between preterm twins on stress response after heel lance.METHODS: Using a multisite randomized controlled trial design, stable preterm twins (67 sets, N=134 infants) between 28 and 36 completed weeks' gestational age, stratified by gestational age (≤ and >32 weeks) and site, were randomly assigned to a co-bedding group, cared for continuously in the same incubator or crib or a standard care group, cared for in a separate incubator or crib, and underwent a medically indicated heel lance after at least 24 hours and no greater than 10 days of group allocation. The reported outcome was cortisol from saliva samples from 89 twins (n=49 co-bedding, n=40 standard care) collected immediately before the heel lance (baseline levels) and 113 twins (n=58 co-bedding, n=55 standard care) collected 20 minutes after heel lance (stress levels) as an index of stress response.RESULTS: No group differences were noted in baseline salivary cortisol levels: 0.36 μg/dL (SD 0.25) in the co-bedding group and 0.43 μg/dL (SD 0.50) in the standard care group. Twenty minutes after lance, levels were significantly lower in the co-bedding group, 0.28 μg/dL (SD 0.25) versus 0.50 μg/dL (SD 0.73) in the standard group (P=0.04). Similarly, the mean of paired changes in salivary cortisol from baseline was lower in the co-bedding group (-0.06 μg/dL) compared with the standard care group (0.14 μg/dL, P<0.05).DISCUSSION: Co-bedding attenuates the stress response of preterm twins undergoing heel lance.TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT009176. |
DOI | 10.1097/AJP.0000000000000015 |
Alternate Journal | Clin J Pain |
PubMed ID | 24300226 |
Grant List | / / Canadian Institutes of Health Research / Canada |