Clocks within the Master Gland: Hypophyseal Rhythms and Their Physiological Significance.

TitleClocks within the Master Gland: Hypophyseal Rhythms and Their Physiological Significance.
Publication TypeJournal Article
Year of Publication2015
AuthorsLin X-W, Blum IDavid, Storch K-F
JournalJ Biol Rhythms
Volume30
Issue4
Pagination263-76
Date Published2015 Aug
ISSN1552-4531
Abstract

Various aspects of mammalian endocrine physiology show a time-of-day variation with a period of 24 h, which represents an adaptation to the daily environmental fluctuations resulting from the rotation of the earth. These 24-h rhythms in hormone abundance and consequently hormone function may rely on rhythmic signals produced by the master circadian clock, which resides in the suprachiasmatic nucleus and is thought to chiefly dictate the pattern of rest and activity in mammals in conjunction with the light/dark (LD) cycle. However, it is likely that clocks intrinsic to elements of the endocrine axes also contribute to the 24-h rhythms in hormone function. Here we review the evidence for rhythm generation in the endocrine master gland, the pituitary, and its physiological significance in the context of endocrine axes regulation and function.

DOI10.1177/0748730415580881
Alternate JournalJ. Biol. Rhythms
PubMed ID25926680
Grant List / / Canadian Institutes of Health Research / Canada