Catechol-o-methyltransferase gene and executive function in children with ADHD.

TitleCatechol-o-methyltransferase gene and executive function in children with ADHD.
Publication TypeJournal Article
Year of Publication2014
AuthorsChoudhry Z, Sengupta S, Thakur G, Page V, Schmitz N, Grizenko N, Joober R
JournalJ Atten Disord
Volume18
Issue3
Pagination202-11
Date Published2014 Apr
ISSN1557-1246
KeywordsAlleles, Attention Deficit Disorder with Hyperactivity, Catechol O-Methyltransferase, Child, Executive Function, Female, Genotype, Haplotypes, Humans, Male, Neuropsychological Tests, Polymorphism, Single Nucleotide
Abstract

OBJECTIVE: To examine the association between functional haplotypes in the catechol-o-methyltransferase (COMT) gene and ADHD diagnosis, and executive function (EF) in children with ADHD.METHOD: COMT single nucleotide polymorphism (SNPs; rs6269, rs4633, rs4818, and rs4680) were genotyped in 445 ADHD children. EF was assessed using Wisconsin Card Sorting Test (WCST), Tower of London, and self-ordered pointing task. COMT haplotypes were tested for association using family-based association testing (fBAT) and quantitative trait analyses.RESULTS: fBAT analysis showed no association between COMT alleles/haplotypes and ADHD diagnosis and EF parameters. Using ANCOVA in the Caucasian only sample, significant associations between COMT haplotypes, and WCST indices were observed. However, after correction for multipletesting, the only significant effect observed was between rs6269 and the number of categories completed (a measure of concept formation ability) on the WCST, F(1,285) = 8.92, p = .003.CONCLUSION: These results tentatively implicate COMT gene in modulating EF in children with ADHD.

DOI10.1177/1087054712438135
Alternate JournalJ Atten Disord
PubMed ID22451510
Grant List / / Canadian Institutes of Health Research / Canada