C-reactive protein, depressive symptoms, and risk of diabetes: results from the English Longitudinal Study of Ageing (ELSA).

TitleC-reactive protein, depressive symptoms, and risk of diabetes: results from the English Longitudinal Study of Ageing (ELSA).
Publication TypeJournal Article
Year of Publication2014
AuthorsAu B, Smith KJ, Gariépy G, Schmitz N
JournalJ Psychosom Res
Volume77
Issue3
Pagination180-6
Date Published2014 Sep
ISSN1879-1360
KeywordsAged, Aging, Biomarkers, C-Reactive Protein, Depression, Diabetes Mellitus, Type 2, England, Female, Humans, Incidence, Independent Living, Inflammation, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Research Design, Risk, Self Report
Abstract

OBJECTIVES: Raised levels of C-reactive protein (CRP), an inflammatory biomarker, and depressive symptoms are both independently linked to risk of diabetes. The purpose of this study was to assess the joint association of CRP and depressive symptomatology with diabetes incidence in a representative sample of English people ≥50 years old.METHOD: Data were from the English Longitudinal Study of Ageing, a prospective study of community-dwelling older adults. The sample was comprised of 4955 participants without self-reported doctor-diagnosed diabetes at baseline. High CRP level was dichotomized as >3 mg/L. Elevated depressive symptomatology was defined as ≥4 using the 8-item Center for Epidemiologic Studies Depression Scale. Incident diabetes was determined based on newly self-reported doctor-diagnosed diabetes. Cox proportional hazard regressions were used to examine the association between CRP and depressive symptoms with incidence of type 2 diabetes.RESULTS: During approximately 63.2 months of follow-up, 194 participants reported diabetes diagnosis. After adjustment for socio-demographics, lifestyle behaviors, clinical factors, and BMI, the hazard ratio for diabetes was 1.63 (95% CI 0.88-3.01) for people with elevated depressive symptoms only, 1.43 (95% CI 0.99-2.07) for people with high CRP only, and 2.03 (95% CI 1.14-3.61) for people with both high CRP and elevated depressive symptoms.CONCLUSION: The presence of both high CRP levels and elevated depressive symptoms was associated with risk of diabetes. Further investigation into this relationship could aid in understanding the mechanisms underlying inflammation, depression, and diabetes.

DOI10.1016/j.jpsychores.2014.07.012
Alternate JournalJ Psychosom Res
PubMed ID25128285
Grant ListMOP 106514 / / Canadian Institutes of Health Research / Canada

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