Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume.
|Title||Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Ritchie SJ, Dickie DAlexander, Cox SR, Hernández MDel CVald, Sibbett R, Pattie A, Anblagan D, Redmond P, Royle NA, Corley J, Maniega SMuñoz, Taylor AM, Karama S, Booth T, Gow AJ, Starr JM, Bastin ME, Wardlaw JM, Deary IJ|
|Date Published||2018 Feb|
Fully characterizing age differences in the brain is a key task for combating aging-related cognitive decline. Using propensity score matching on 2 independent, narrow-age cohorts, we used data on childhood cognitive ability, socioeconomic background, and intracranial volume to match participants at mean age of 92 years (n = 42) to very similar participants at mean age of 73 years (n = 126). Examining a variety of global and regional structural neuroimaging variables, there were large differences in gray and white matter volumes, cortical surface area, cortical thickness, and white matter hyperintensity volume and spatial extent. In a mediation analysis, the total volume of white matter hyperintensities and total cortical surface area jointly mediated 24.9% of the relation between age and general cognitive ability (tissue volumes and cortical thickness were not significant mediators in this analysis). These findings provide an unusual and valuable perspective on neurostructural aging, in which brains from the 8th and 10th decades of life differ widely despite the same cognitive, socioeconomic, and brain-volumetric starting points.
|Alternate Journal||Neurobiol. Aging|
|PubMed Central ID||PMC5759896|
|Grant List||/ / Wellcome Trust / United Kingdom|